교수님, 제가 더 걱정이 되요.
이러시면 곤란해요 2008/10/17 10:40
얼마 전 신문의 과학면을 시끄럽게 만들었던 김 교수님의 논문들을 읽어봤습니다. 그리고 Déjà vu 프로그램이 찾은 2건과 브릭에 올라온 2건, 그리고 제가 찾은 한건 더 합해서 이제까지 5건이 표절로 의심되는 논문을 정리해 봤습니다. 그냥 CH Kim이 책임저자로 있는 논문을 구글링하고, 그 중 처음 클릭해서 들어가서 초록 뒷부분을 copy하고 그 부분으로 검색을 했더니 나오는군요. 원래논문이 대한침구학회지 논문이라서 pdf 파일을 받으려고 KISTI 가입하는데 더 많은 시간이 걸렸습니다. 더 찾아볼까 하다가 시간도 없고 줄줄이 사탕처럼 엮여 나올까봐 걱정도 되는군요. 생물학연구정보센터에 올라온 관련 글들에 링크를 달았습니다(링크를 누르시면 원본 논문을 보실 수 있습니다).
사례 1.
원문 논문
HUTCHINGS, P., HEDLUND, G, DAWE, K, HOWLETT, S, COOKE, A. Effect of the synthetic immunomodulator, Linomide, on experimental models of thyroiditis. Immunology. 1999;96:340-347,
표절 의심 논문
Kang, Bong-Seok, Han, Ji-Yeong, Kang, Sung-Koo, Kim, Dong-IL, Kim, June-Ki and Kim, Cheorl-Ho. Effect of the Traditional Korean Immunomodulating Formulation, Gamguntang (GGT), on Experimental Thyroiditis Model. Immunopharmacology and Immunotoxicology 2006;28:1,51- 66.
수법: 일치하는 데이터의 그래프 형태 변경(꺽은선 그래프 -> 막대 그래프)
사례 2.
원래 논문
Marie-Pierre Brazillet, Fre´ de´ ric Batteux, Orly Abehsira-Amar, Ferdinando Nicoletti, Jeannine Charreire. Induction of experimental autoimmune thyroiditis by heat-denatured porcine thyroglobulin: a Tc1-mediated disease. Eur. J. Immunol. 1999. 29: 1342–1352
표절 의심 논문
Kang, Bong-Seok, Chung, Tae-Wook, Moon, Jin-Young, Lim, Jong-Kook, Shon, Yun-Hee, Nam, Kyung-Soo, Kim, Dong-Soo, Jeon, Byung-Hoon and Kim, Cheorl-Ho. Induction of a TC1-Mediated Experimental Autoimmune Thyroiditis by Deglycosylated Porcine Thyroglobulin. Immunopharmacology and Immunotoxicology 2005;26:355-372.
수법:
Anti- Kk mAB abrogated the Tg-specific cytotoxic response by 86%, whereas anti-I-Ak induced a 36% inhibition that was comparable to that of control mAB. 이라는 문장이
Anti- Kk mAB abrogated the Tg-specific cytotoxic response by 87%, whereas anti-I-Ak induced a 38% inhibition that was comparable to that of control mAB. 이라는 문장으로 변형.
그 외에도 Abstract, Introduction, Result 등의 내용을 숫자만 바꿔서 copy & paste
사례 3.
원래 논문
Inmaculada Rioja, Amalia Ubeda, M. Carmen Terencio, Isabel Guille´n, Ricardo Riguera, Jose´M. Quintela, Carlos Peinador, Liliana M. Gonza´lez, M. Jose´ Alcaraz. An anti-inflammatory ditriazine inhibiting leukocyte functions and expression of inducible nitric oxide synthase and cyclo-oxygenase-2. European Journal of Pharmacology 2000;397:207–217
표절 의심 논문
Un-Ho Jin, Soon-Gi Park, Seok-Jong Suh, June-Ki Kim, Dong-Soo Kim, Sung-Kwon Moon, Young-Choon Lee, Won-Hwan Park, Cheorl-Ho Kim. Inhibitory Effect of Panax notoginseng on Nitric Oxide Synthase, Cyclo-oxygenase-2 and Neutrophil Functions. Phytother. Res. 2007;21:142–148.
In contrast, our compound DTD, seems to affect cell activation at a site common to different signaling pathways as it inhibited responses induced by fMLP, PAF, TPA or ionophore A23187.
The induction of NO synthase and cyclo-oxygenase-2 greatly increases the synthesis of NO and prostaglandins, which contribute to the pathophysiology of various inflammatory processes. In addition, NO has been implicated in septic shock Cobb and Danner, 1996.. Inducible NO synthase inhibition results in modulation of the inflammatory response in different models such as subcutaneous granuloma formation in rats Iuvone et al., 1994. and delayed paw swelling induced by carrageenan in mice Ianaro et al., 1994.. In humans, the production of NO by activated macrophages or neutrophils can be an index of bronchial inflammation and a mechanism for increasing asthmatic inflammation Alving et al., 1993.. Furthermore, NO has been shown, in in vitro and in vivo studies, to increase the production of pro-inflammatory prosta-glandins Salvemini et al., 1993, 1995.. On the other hand, overproduction of prostaglandins by cyclo-oxygenase-2 expression in vivo has been reported for chronic inflamma-tory conditions such as rheumatoid arthritis Kang et al., 1996. and experimental models of inflammation Seibert et al., 1994; Vane et al., 1994.. In the present study, we have shown that DTD inhibited the production of NO and prostaglandin E in murine peritoneal macrophages stimu- 2 lated by lipopolysaccharide. The inhibition was dose-dependent without any evidence of a cytotoxic effect. Nevertheless, this compound was ineffective when inducible NO synthase and cyclo-oxygenase-2 were already expressed. 의 문장을 통째로 copy & paste 해서 아래 문장으로 변형.
PN seems to affect cell activation at a site common to different signaling pathways as it inhibited responses induced by fMLP, PAF, TPA or ionophore A23187.
The induction of iNOS and COX-2 greatly increases the synthesis of NO and PGs. iNOS inhibition results in modulation of the inflammatory response and delayed paw swelling induced by carrageenan in mice (Ianaro et al., 1994). Furthermore, NO has been shown, in in vitro and in vivo studies, to increase the production of proinflammatory PGs (Gross and Levi, 1992). Overproduction of PGs by COX-2 expression in vivo has been reported for chronic inflammatory conditions such as rheumatoid arthritis (Kang et al., 1996) and experimental models of inflammation (Salvemini et al., 1992). PN inhibited the production of NO and PGE2 in murine peritoneal macrophages stimulated by LPS. The inhibition was dose-dependent without any evidence of a cytotoxic effect. Western blot analysis of mouse peritoneal macrophage lysates showed that iNOS and COX-2 protein expression was reduced by the presence.
사례 4.
원래 논문
Y. Uchiyama, H. Takamori, K. Miyama, E. Takano, H. Nakajima, T. Sato, T. Nakamura. Modulation of Bone Mass, Strength, and Turnover by a New Benzamide Compound, DU-6712, in Adjuvant-Induced Arthritic Rats Calcif Tissue Int 1998;62:519–526
표절 의심 논문
Kyung-Ho Kim, Kap-Sung Kim, Byeong-Joon Choi, Kang-Hyun Chung, Young-Chae Chang, Seung-Duk Lee, Kwan-Kyu Park, Hyung-Min Kimd, Cheorl-Ho Kim. Anti-bone resorption activity of deer antler aqua-acupunture, the pilose antler of Cervus korean TEMMINCK var. mantchuricus Swinhoe
(Nokyong) in adjuvant-induced arthritic rats. Journal of Ethnopharmacology 2005;96: 497–506
수법: 일단 특정 약물의 효과를 분석한 논문을 찾아서 그 특정 약물을 녹용 이나 다른 한국산 천연물로 바꾼 뒤 논문의 모든 내용을 카피. 원저의 Figure 1, 2는 Table 1, 2로 항목을 바꿨고 그 다음 표부터는 그대로 카피. Discussion 후반부는 거의 동일.
사례 5.
원래 논문
Park, Jun-Sung; Kim, Kyung-Ho; Jo, Hyun-Seog; Kim, Kap-Sung; Hwang, Min-Seob, Inhibitory effect of Ulmus davidiana Planch extracts on bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts. 대한침구학회지 2005;22:55-70
표절 의심 논문
Young-Guk Park, Young-Hun Kim, Sung-Koo Kang, Cheorl-Ho Kim. cAMP-PKA signaling pathway regulates bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts. International Immunopharmacology 2006;6:947-956
수법: 단어 변경 후 카피
‘Since secreted proenzymes have the potential to reenter the cell via mannose-6-phosphate (M6P) receptor, to prevent this possibility, we tested WT and UD in the absence or presence of M6P. Inhibition of Cat K processing by WT or UD was observed in a dose-dependent manner. Furthermore, the addition of M6P resulted in enhanced potency of WT and UD. Conclusion : UD dose-dependently inhibited in vitro bone resorption with a potency similar to that observed for inhibition of Cat K processing.’
‘Since secreted proenzymes have the potential to reenter the cell via M6P receptor, to prevent this possibility, we tested cAMP antagonist Rp-cAMP and the PKA inhibitors KT5720 and H89 in the absence or presence of M6P. Inhibition of Cat K processing by Rp-cAMP, KT5720 or H89 was observed in a dose-dependent manner. Furthermore, the addition of M6P resulted in enhanced potency of Rp-cAMP, KT5720 and H89, which dose-dependently inhibited in vitro bone resorption with potency similar to that observed for inhibition of Cat K processing.’
사례 1.
원문 논문
HUTCHINGS, P., HEDLUND, G, DAWE, K, HOWLETT, S, COOKE, A. Effect of the synthetic immunomodulator, Linomide, on experimental models of thyroiditis. Immunology. 1999;96:340-347,
표절 의심 논문
Kang, Bong-Seok, Han, Ji-Yeong, Kang, Sung-Koo, Kim, Dong-IL, Kim, June-Ki and Kim, Cheorl-Ho. Effect of the Traditional Korean Immunomodulating Formulation, Gamguntang (GGT), on Experimental Thyroiditis Model. Immunopharmacology and Immunotoxicology 2006;28:1,51- 66.
수법: 일치하는 데이터의 그래프 형태 변경(꺽은선 그래프 -> 막대 그래프)
사례 2.
원래 논문
Marie-Pierre Brazillet, Fre´ de´ ric Batteux, Orly Abehsira-Amar, Ferdinando Nicoletti, Jeannine Charreire. Induction of experimental autoimmune thyroiditis by heat-denatured porcine thyroglobulin: a Tc1-mediated disease. Eur. J. Immunol. 1999. 29: 1342–1352
표절 의심 논문
Kang, Bong-Seok, Chung, Tae-Wook, Moon, Jin-Young, Lim, Jong-Kook, Shon, Yun-Hee, Nam, Kyung-Soo, Kim, Dong-Soo, Jeon, Byung-Hoon and Kim, Cheorl-Ho. Induction of a TC1-Mediated Experimental Autoimmune Thyroiditis by Deglycosylated Porcine Thyroglobulin. Immunopharmacology and Immunotoxicology 2005;26:355-372.
수법:
Anti- Kk mAB abrogated the Tg-specific cytotoxic response by 86%, whereas anti-I-Ak induced a 36% inhibition that was comparable to that of control mAB. 이라는 문장이
Anti- Kk mAB abrogated the Tg-specific cytotoxic response by 87%, whereas anti-I-Ak induced a 38% inhibition that was comparable to that of control mAB. 이라는 문장으로 변형.
그 외에도 Abstract, Introduction, Result 등의 내용을 숫자만 바꿔서 copy & paste
사례 3.
원래 논문
Inmaculada Rioja, Amalia Ubeda, M. Carmen Terencio, Isabel Guille´n, Ricardo Riguera, Jose´M. Quintela, Carlos Peinador, Liliana M. Gonza´lez, M. Jose´ Alcaraz. An anti-inflammatory ditriazine inhibiting leukocyte functions and expression of inducible nitric oxide synthase and cyclo-oxygenase-2. European Journal of Pharmacology 2000;397:207–217
표절 의심 논문
Un-Ho Jin, Soon-Gi Park, Seok-Jong Suh, June-Ki Kim, Dong-Soo Kim, Sung-Kwon Moon, Young-Choon Lee, Won-Hwan Park, Cheorl-Ho Kim. Inhibitory Effect of Panax notoginseng on Nitric Oxide Synthase, Cyclo-oxygenase-2 and Neutrophil Functions. Phytother. Res. 2007;21:142–148.
In contrast, our compound DTD, seems to affect cell activation at a site common to different signaling pathways as it inhibited responses induced by fMLP, PAF, TPA or ionophore A23187.
The induction of NO synthase and cyclo-oxygenase-2 greatly increases the synthesis of NO and prostaglandins, which contribute to the pathophysiology of various inflammatory processes. In addition, NO has been implicated in septic shock Cobb and Danner, 1996.. Inducible NO synthase inhibition results in modulation of the inflammatory response in different models such as subcutaneous granuloma formation in rats Iuvone et al., 1994. and delayed paw swelling induced by carrageenan in mice Ianaro et al., 1994.. In humans, the production of NO by activated macrophages or neutrophils can be an index of bronchial inflammation and a mechanism for increasing asthmatic inflammation Alving et al., 1993.. Furthermore, NO has been shown, in in vitro and in vivo studies, to increase the production of pro-inflammatory prosta-glandins Salvemini et al., 1993, 1995.. On the other hand, overproduction of prostaglandins by cyclo-oxygenase-2 expression in vivo has been reported for chronic inflamma-tory conditions such as rheumatoid arthritis Kang et al., 1996. and experimental models of inflammation Seibert et al., 1994; Vane et al., 1994.. In the present study, we have shown that DTD inhibited the production of NO and prostaglandin E in murine peritoneal macrophages stimu- 2 lated by lipopolysaccharide. The inhibition was dose-dependent without any evidence of a cytotoxic effect. Nevertheless, this compound was ineffective when inducible NO synthase and cyclo-oxygenase-2 were already expressed. 의 문장을 통째로 copy & paste 해서 아래 문장으로 변형.
PN seems to affect cell activation at a site common to different signaling pathways as it inhibited responses induced by fMLP, PAF, TPA or ionophore A23187.
The induction of iNOS and COX-2 greatly increases the synthesis of NO and PGs. iNOS inhibition results in modulation of the inflammatory response and delayed paw swelling induced by carrageenan in mice (Ianaro et al., 1994). Furthermore, NO has been shown, in in vitro and in vivo studies, to increase the production of proinflammatory PGs (Gross and Levi, 1992). Overproduction of PGs by COX-2 expression in vivo has been reported for chronic inflammatory conditions such as rheumatoid arthritis (Kang et al., 1996) and experimental models of inflammation (Salvemini et al., 1992). PN inhibited the production of NO and PGE2 in murine peritoneal macrophages stimulated by LPS. The inhibition was dose-dependent without any evidence of a cytotoxic effect. Western blot analysis of mouse peritoneal macrophage lysates showed that iNOS and COX-2 protein expression was reduced by the presence.
사례 4.
원래 논문
Y. Uchiyama, H. Takamori, K. Miyama, E. Takano, H. Nakajima, T. Sato, T. Nakamura. Modulation of Bone Mass, Strength, and Turnover by a New Benzamide Compound, DU-6712, in Adjuvant-Induced Arthritic Rats Calcif Tissue Int 1998;62:519–526
표절 의심 논문
Kyung-Ho Kim, Kap-Sung Kim, Byeong-Joon Choi, Kang-Hyun Chung, Young-Chae Chang, Seung-Duk Lee, Kwan-Kyu Park, Hyung-Min Kimd, Cheorl-Ho Kim. Anti-bone resorption activity of deer antler aqua-acupunture, the pilose antler of Cervus korean TEMMINCK var. mantchuricus Swinhoe
(Nokyong) in adjuvant-induced arthritic rats. Journal of Ethnopharmacology 2005;96: 497–506
수법: 일단 특정 약물의 효과를 분석한 논문을 찾아서 그 특정 약물을 녹용 이나 다른 한국산 천연물로 바꾼 뒤 논문의 모든 내용을 카피. 원저의 Figure 1, 2는 Table 1, 2로 항목을 바꿨고 그 다음 표부터는 그대로 카피. Discussion 후반부는 거의 동일.
사례 5.
원래 논문
Park, Jun-Sung; Kim, Kyung-Ho; Jo, Hyun-Seog; Kim, Kap-Sung; Hwang, Min-Seob, Inhibitory effect of Ulmus davidiana Planch extracts on bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts. 대한침구학회지 2005;22:55-70
표절 의심 논문
Young-Guk Park, Young-Hun Kim, Sung-Koo Kang, Cheorl-Ho Kim. cAMP-PKA signaling pathway regulates bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts. International Immunopharmacology 2006;6:947-956
수법: 단어 변경 후 카피
‘Since secreted proenzymes have the potential to reenter the cell via mannose-6-phosphate (M6P) receptor, to prevent this possibility, we tested WT and UD in the absence or presence of M6P. Inhibition of Cat K processing by WT or UD was observed in a dose-dependent manner. Furthermore, the addition of M6P resulted in enhanced potency of WT and UD. Conclusion : UD dose-dependently inhibited in vitro bone resorption with a potency similar to that observed for inhibition of Cat K processing.’
‘Since secreted proenzymes have the potential to reenter the cell via M6P receptor, to prevent this possibility, we tested cAMP antagonist Rp-cAMP and the PKA inhibitors KT5720 and H89 in the absence or presence of M6P. Inhibition of Cat K processing by Rp-cAMP, KT5720 or H89 was observed in a dose-dependent manner. Furthermore, the addition of M6P resulted in enhanced potency of Rp-cAMP, KT5720 and H89, which dose-dependently inhibited in vitro bone resorption with potency similar to that observed for inhibition of Cat K processing.’
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